ERIODICTYOL/LEMON BIOFLAVONOID
Selfridge, Grant: VIII Nerve High Tone Deafness From a Nutritional Standpoint (A Further Contribution). Annals of Otology, Rhinology and Laryngo9logy 48:608-631, 1939.

Wolfson, R.J., Treatment of Menier's disease (1969) pp553-567. "From examining the results of a therapeutic trial in 122 cases of Meniere's disease…it seems to us that eriodictyol glycoside (in the lemon bioflavonoid complex) has a beneficial therapeutic or biologic effect on certain individuals with sensori-neural hearing loss, usually that is associated with Vertigo and other symptoms and signs in the symptom complex called Meniere's disease."

Koide, Yasushi: Biochemical Problems of Inner Ear Disease. Acta Otolaryng. 53:-523-535, 1961. Williams suggests the Koide research supports the theory that "eriodictyol may act on histidine decarboxylase or on the storage, or release or destruction or both, of one of the amines or one of the polypeptides which appear to play a major part in control of the microcirculation. 1-4
1Martin, G.J., Carley, John, Jr., and Moss, J.N.: Aglycone Flavonoids in Experimental Chemotherapy. Exper. Med. And Surg. 7:391-393, 1949.
2Schayer, R.W.: Significance of Induced Synthesis of Histamine in Physiology and Pathology. Chemotherapia 3:128-136, 1961.
3Schayer, R.W.: Evidence That Induced Histamine Is an Intrinsic Regulator of the Microcirculatory System. Am. J. Physiology. 202:66-72, 1962.
4Nomura, Yasuya: Observations on the Microcirculation of the Choclea: An Experimental Study. Annals of Otology, Rhinology and Laryngology 70:1037-1054, 1961.

Williams, H.L. et al Eriodictyol Glycoside in the treatment of Meniere's disease Ann. Otol. Rhinol., Lar (1963), 72, 4, 1082.

ASCORBIC ACID/ VITAMIN C
Morch, Paul: Traitement de la maladie de Meniere et d'autres affections s'accompagnant de bourdonnements otogenes et de vertiges par les vitamins. Acta Otolaryng. 27:629-637, 1939. "Deficiency of ascorbic acid apparently was the first vitamin deficiency to be held responsible for the symptoms of Meniere's disease."

CHOLINE
Selfridge and Williams advocate that choline be included in Vitamin B therapy for Meniere's disease. "Fatty livers and hemorrhagic kidneys appear specifically to related to the need for Choline."

INOSITOL
Williams and Selfridge indicated that Inositol be recommended for "vitamin preparation for the treatment of sensori-neural hearing loss."

THIAMINE
McIlwain, Henry: Biochemistry and the Central Nervous System. Little, Brown and Company, Boston, 1955. McIlwain suggested that the vitamins that most effect the central nervous system include thiamin, vitamins B6 and B12.

PANTOTHENIC ACID
Robison, M.M: Personal communication to the authors of Williams et. al. Pantothenate is reported by Robison to have "relieved the loss of hearing produced by dihydrostreptomycin."